research data . Dataset . 2016

RMND5 from Xenopus laevis Is an E3 Ubiquitin-Ligase and Functions in Early Embryonic Forebrain Development

Pfirrmann, Thorsten; Villavicencio-Lorini, Pablo; K. Subudhi, Abinash; Menssen, Ruth; H. Wolf, Dieter; Hollemann, Thomas;
  • Published: 01 Jan 2016
  • Publisher: Figshare
<div><p>In <i>Saccharomyces cerevisiae</i> the Gid-complex functions as an ubiquitin-ligase complex that regulates the metabolic switch between glycolysis and gluconeogenesis. In higher organisms six conserved Gid proteins form the CTLH protein-complex with unknown function. Here we show that Rmnd5, the Gid2 orthologue from Xenopus laevis, is an ubiquitin-ligase embedded in a high molecular weight complex. Expression of <i>rmnd5</i> is strongest in neuronal ectoderm, prospective brain, eyes and ciliated cells of the skin and its suppression results in malformations of the fore- and midbrain. We therefore suggest that <i>Xenopus laevis</i> Rmnd5, as a subunit of ...
free text keywords: Biological Sciences, Gid proteins form, Embryonic Forebrain Development, Xenopus laevis, ctlh, RMND, function, fore, midbrain, Gid 2 orthologue
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Dataset . 2016
Provider: figshare
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