research data . Dataset . 2016

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Open Access
  • Published: 18 Jan 2016
Abstract
<div><p>Background</p><p>The impact of raltegravir-resistant HIV-1 minority variants (MVs) on raltegravir treatment failure is unknown. Illumina sequencing offers greater throughput than 454, but sequence analysis tools for viral sequencing are needed. We evaluated Illumina and 454 for the detection of HIV-1 raltegravir-resistant MVs.</p><p>Methods</p><p>A5262 was a single-arm study of raltegravir and darunavir/ritonavir in treatment-naïve patients. Pre-treatment plasma was obtained from 5 participants with raltegravir resistance at the time of virologic failure. A control library was created by pooling integrase clones at predefined proportions. Multiplexed seq...
Subjects
free text keywords: Medicine, Biological Sciences, Mathematics, Computational biology, genomics, Genome sequencing, Sequence analysis, microbiology, Virology, antivirals, statistics, Biostatistics, Infectious diseases, Viral diseases, hiv, HIV diagnosis and management, Retrovirology and HIV immunopathogenesis, illumina, 454, sequencing, failing, raltegravir-based, antiretroviral
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Dataset . 2016
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