research data . Dataset . 2016

Compartmental and Temporal Dynamics of Chronic Inflammation and Airway Remodelling in a Chronic Asthma Mouse Model

Alrifai, Mohammed; M. Marsh, Leigh; Dicke, Tanja; Kılıç, Ayse; L. Conrad, Melanie; Renz, Harald; Garn, Holger;
Open Access
  • Published: 01 Jan 2016
  • Publisher: Figshare
Abstract
<div><p>Background</p><p>Allergic asthma is associated with chronic airway inflammation and progressive airway remodelling. However, the dynamics of the development of these features and their spontaneous and pharmacological reversibility are still poorly understood. We have therefore investigated the dynamics of airway remodelling and repair in an experimental asthma model and studied how pharmacological intervention affects these processes.</p><p>Methods</p><p>Using BALB/c mice, the kinetics of chronic asthma progression and resolution were characterised in absence and presence of inhaled corticosteroid (ICS) treatment. Airway inflammation and remodelling was ...
Subjects
Medical Subject Headings: respiratory tract diseases
free text keywords: Medicine, Biological Sciences, Anatomy and physiology, Respiratory system, Respiratory physiology, immunology, Allergy and hypersensitivity, Model organisms, Animal models, mouse, Clinical immunology, Clinical research design, Animal models of disease, Pulmonology, asthma, temporal, inflammation, airway, remodelling
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Dataset . 2016
Provider: figshare
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