research data . Dataset . 2016

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Open Access
  • Published: 18 Jan 2016
<div><p>The most simple and commonly used approach for genetic associations is the case-control study design of unrelated people. This design is susceptible to population stratification. This problem is obviated in family-based studies, but it is usually difficult to accumulate large enough samples of well-characterized families. We addressed empirically whether the two designs give similar estimates of association in 93 investigations where both unrelated case-control and family-based designs had been employed. Estimated odds ratios differed beyond chance between the two designs in only four instances (4%). The summary relative odds ratio (ROR) (the ratio of od...
free text keywords: Genetics, Biotechnology, family-based, unrelated, case-control, designs, associations
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Dataset . 2016
Provider: figshare
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