research data . Dataset . 2016

No title available

Open Access
  • Published: 18 Jan 2016
Abstract
<div><p>Epstein-Barr virus (EBV) encoded transcription factor Zta (BZLF1, ZEBRA, EB1) is the prototype of a class of transcription factor (including C/EBPalpha) that interact with CpG-containing DNA response elements in a methylation-dependent manner. The EBV genome undergoes a biphasic methylation cycle; it is extensively methylated during viral latency but is reset to an unmethylated state following viral lytic replication. Zta is expressed transiently following infection and again during the switch between latency and lytic replication. The requirement for CpG-methylation at critical Zta response elements (ZREs) has been proposed to regulate EBV replication, ...
Subjects
free text keywords: Biochemistry, Microbiology, Genetics, Cancer, epigenetic, viral, life-cycle, dna-methylation, transcription
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Dataset . 2016
Provider: figshare
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