research data . Dataset . 2016

Concept, Design and Implementation of a Cardiovascular Gene-Centric 50 K SNP Array for Large-Scale Genomic Association Studies

J. Keating, Brendan; Tischfield, Sam; S. Murray, Sarah; Bhangale, Tushar; S. Price, Thomas; T. Glessner, Joseph; Galver, Luana; C. Barrett, Jeffrey; F. A. Grant, Struan; N. Farlow, Deborah; ...
Open Access
  • Published: 01 Jan 2016
  • Publisher: Figshare
Abstract
<div><p>A wealth of genetic associations for cardiovascular and metabolic phenotypes in humans has been accumulating over the last decade, in particular a large number of loci derived from recent genome wide association studies (GWAS). True complex disease-associated loci often exert modest effects, so their delineation currently requires integration of diverse phenotypic data from large studies to ensure robust meta-analyses. We have designed a gene-centric 50 K single nucleotide polymorphism (SNP) array to assess potentially relevant loci across a range of cardiovascular, metabolic and inflammatory syndromes. The array utilizes a “cosmopolitan” tagging approac...
Subjects
free text keywords: Medicine, Genetics, Biotechnology, cardiovascular, gene-centric, 50, snp, large-scale, genomic, studies
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Dataset . 2016
Provider: figshare
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