research data . Dataset . 2016

Novel Insulin Sensitizer Modulates Nutrient Sensing Pathways and Maintains β-Cell Phenotype in Human Islets

Rohatgi, Nidhi; Aly, Haytham; A. Marshall, Connie; G. McDonald, William; F. Kletzien, Rolf; R. Colca, Jerry; L. McDaniel, Michael;
  • Published: 01 Jan 2016
  • Publisher: Figshare
Abstract
<div><p>Major bottlenecks in the expansion of human β-cell mass are limited proliferation, loss of β-cell phenotype, and increased apoptosis. In our previous studies, activation of Wnt and mTOR signaling significantly enhanced human β-cell proliferation. However, isolated human islets displayed insulin signaling pathway resistance, due in part to chronic activation of mTOR/S6K1 signaling that results in negative feedback of the insulin signaling pathway and a loss of Akt phosphorylation and insulin content. We evaluated the effects of a new generation insulin sensitizer, MSDC-0160, on restoring insulin/IGF-1 sensitivity and insulin content in human β-cells. This...
Subjects
free text keywords: Medicine, Biological Sciences, Biochemistry, metabolism, Metabolic pathways, Molecular cell biology, Signal transduction, Signaling cascades, Insulin signaling cascade, Drugs and devices, Pharmacodynamics, Endocrinology, Diabetic endocrinology, Diabetes mellitus type 1, Diabetes mellitus type 2, Endocrine physiology, insulin, sensitizer, modulates, sensing, pathways, maintains, phenotype
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Dataset . 2016
Provider: figshare
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