research data . Dataset . 2016

Identification, Replication, and Functional Fine-Mapping of Expression Quantitative Trait Loci in Primary Human Liver Tissue

Innocenti, Federico; M. Cooper, Gregory; B. Stanaway, Ian; R. Gamazon, Eric; D. Smith, Joshua; Mirkov, Snezana; Ramirez, Jacqueline; Liu, Wanqing; S. Lin, Yvonne; Moloney, Cliona; ...
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Open Access
  • Published: 01 Jan 2016
  • Publisher: Figshare
Abstract
<div><p>The discovery of expression quantitative trait loci (“eQTLs”) can help to unravel genetic contributions to complex traits. We identified genetic determinants of human liver gene expression variation using two independent collections of primary tissue profiled with Agilent (n = 206) and Illumina (n = 60) expression arrays and Illumina SNP genotyping (550K), and we also incorporated data from a published study (n = 266). We found that ∼30% of SNP-expression correlations in one study failed to replicate in either of the others, even at thresholds yielding high reproducibility in simulations, and we quantified numerous factors affecting reproducibility. Our ...
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doi: 10.1371/journal.pgen.1002078
Subjects
free text keywords: Genetics, fine-mapping, of, quantitative, loci
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Dataset . 2016
Provider: figshare
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