research data . Dataset . 2016

Analysis and Application of European Genetic Substructure Using 300 K SNP Information

Tian, Chao; M Plenge, Robert; Ransom, Michael; Lee, Annette; Villoslada, Pablo; Selmi, Carlo; Klareskog, Lars; E Pulver, Ann; Qi, Lihong; K Gregersen, Peter; ...
  • Published: 01 Jan 2016
  • Publisher: Figshare
Abstract
<div><p>European population genetic substructure was examined in a diverse set of >1,000 individuals of European descent, each genotyped with >300 K SNPs. Both STRUCTURE and principal component analyses (PCA) showed the largest division/principal component (PC) differentiated northern from southern European ancestry. A second PC further separated Italian, Spanish, and Greek individuals from those of Ashkenazi Jewish ancestry as well as distinguishing among northern European populations. In separate analyses of northern European participants other substructure relationships were discerned showing a west to east gradient. Application of this substructure informati...
Subjects
free text keywords: Genetics, european, substructure, 300, snp
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Dataset . 2016
Provider: figshare
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