research data . Dataset . 2016

RAN-Binding Protein 9 is Involved in Alternative Splicing and is Critical for Male Germ Cell Development and Male Fertility

Bao, Jianqiang; Tang, Chong; Li, Jiachen; Zhang, Ying; P. Bhetwal, Bhupal; Zheng, Huili; Yan, Wei;
  • Published: 01 Jan 2016
  • Publisher: Figshare
Abstract
<div><p>As a member of the large Ran-binding protein family, Ran-binding protein 9 (RANBP9) has been suggested to play a critical role in diverse cellular functions in somatic cell lineages <i>in vitro</i>, and this is further supported by the neonatal lethality phenotype in <i>Ranbp9</i> global knockout mice. However, the exact molecular actions of RANBP9 remain largely unknown. By inactivation of <i>Ranbp9</i> specifically in testicular somatic and spermatogenic cells, we discovered that <i>Ranbp9</i> was dispensable for Sertoli cell development and functions, but critical for male germ cell development and male fertility. RIP-Seq and proteomic analyses reveal...
Subjects
free text keywords: Biological Sciences, function, Male Germ Cell Development, fertility, protein, RANBP 9 target, role, spermatogenic cells, germ cell development, mrna, Sertoli cell development, RANBP 9
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Dataset . 2016
Provider: figshare
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