research data . Dataset . 2017

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Open Access
  • Published: 14 Jul 2017
Abstract
<div><p>Introduction</p><p>Buruli ulcer (BU) caused by <i>Mycobacterium ulcerans</i> is effectively treated with rifampicin and streptomycin for 8 weeks but some lesions take several months to heal. We have shown previously that some slowly healing lesions contain mycolactone suggesting continuing infection after antibiotic therapy. Now we have determined how rapidly combined <i>M</i>. <i>ulcerans</i> 16S rRNA reverse transcriptase / IS<i>2404</i> qPCR assay (16S rRNA) became negative during antibiotic treatment and investigated its influence on healing.</p><p>Methods</p><p>Fine needle aspirates and swab samples were obtained for culture, acid fast bacilli (AFB)...
Subjects
free text keywords: Medicine, Microbiology, Molecular Biology, Biotechnology, Immunology, Cancer, 110309 Infectious Diseases, 60506 Virology, Mycobacterium ulcerans, BU, antibiotic therapy, week 4, 2404 qPCR assay Introduction Buruli ulcer, 4 weeks, 12 weeks, AFB, Methods Fine needle aspirates, healing, Kaplan-Meier survival analysis, load, week 4. Conclusions, antibiotic treatment, 8 weeks, M ulcerans 16 S rRNA, Mann Whitney test, Buruli ulcer lesions, baseline, ulcerans 16 S rRNA, 16 S rRNA
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Dataset . 2017
Provider: figshare
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