research data . Dataset . 2016

No title available

Open Access
  • Published: 15 Jan 2016
Abstract
<div><p>Dengue virus (DENV) is a re-emerging arthropod borne flavivirus that infects more than 300 million people worldwide, leading to 50,000 deaths annually. Because dendritic cells (DC) in the skin and blood are the first target cells for DENV, we sought to investigate the early molecular events involved in the host response to the virus in primary human monocyte-derived dendritic cells (Mo-DC). Using a genome-wide transcriptome analysis of DENV2-infected human Mo-DC, three major responses were identified within hours of infection - the activation of IRF3/7/STAT1 and NF-κB-driven antiviral and inflammatory networks, as well as the stimulation of an oxidative ...
Subjects
Medical Subject Headings: virusesbiochemical phenomena, metabolism, and nutritionvirus diseases
free text keywords: Uncategorised, rna, cell death responses, DENV infection, ros, Reactive oxygen species, nox, transcription factor NRF 2, nf, Cellular Oxidative Stress Response Controls, oxidative stress, oxidative stress response, dc, virus, DENV 2 infection, irf
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Dataset . 2016
Provider: figshare
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