research data . Dataset . 2016

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Open Access
  • Published: 17 Feb 2016
Interspecies variation in sensitivity to synthetic chemicals can be orders of magnitude large. Species traits causing the variation can be related to toxicokinetics (uptake, distribution, biotransformation, elimination) or toxicodynamics (interaction with biological target sites). We present an approach to systematically measure and model the contribution of uptake, biotransformation, internal distribution, and elimination kinetics toward species sensitivity differences. The aim is to express sensitivity as target tissue specific, internal lethal concentrations. A case study with the pesticides diazinon, imidacloprid, and propiconazole and the aquatic invertebra...
free text keywords: Medicine, 59999 Environmental Sciences not elsewhere classified, 69999 Biological Sciences not elsewhere classified, 39999 Chemical Sciences not elsewhere classified, Toxicokinetic, species sensitivity differences, toxicodynamic differences, insecticide diazinon, ChemicalsInterspecies variation, baseline toxicity, species traits, target sites, case study, pesticides diazinon, neurotoxicant imidacloprid, uptake, target tissues, invertebrates Gammarus pulex, concentration, propiconazole, target tissue, Interspecies Variation, elimination kinetics, approach, Sensitivity, Gammaridae, biotransformation, Lymnaea stagnalis, Gammarus fossarum
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Dataset . 2016
Provider: figshare
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