[Haplotype analysis of serotonin 2A receptor gene polymorphisms and smoking behavior].
Copyright policy )[Haplotype analysis of serotonin 2A receptor gene polymorphisms and smoking behavior].
In this study, the relationship between the haplotypes consisting of single nucleotide polymorphisms (SNPs) of serotonin 2A receptor (5HT2AR) gene (HTR2A) 102T/C (rs6313) and -1438A/G (rs6311) and smoking behavior was studied among 101 smokers and 99 non-smokers. It was shown that the genotypic and allelic frequencies of these polymorphisms were not associated with the smoking behavior. However, according to haplotype analysis, higher haplotype 1 ((-1438G) G-(102)T) frequency was observed in smokers than in non-smokers (P < 0.05). Pairwise D' and gamma2 values between the two SNPs in this study were 0.916 and 0.805, respectively. The two SNPs thus showed strong linkage disequilibrium with each other. This study suggests that 5-HT2AR gene haplotype (G-T) may be related to smoking behavior.
Adult, Male, Young Adult, Polymorphism, Genetic, Haplotypes, Smoking, Humans, Female, Genetic Predisposition to Disease, Receptor, Serotonin, 5-HT2A, Linkage Disequilibrium
Adult, Male, Young Adult, Polymorphism, Genetic, Haplotypes, Smoking, Humans, Female, Genetic Predisposition to Disease, Receptor, Serotonin, 5-HT2A, Linkage Disequilibrium
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).0 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!