publication . Thesis . 2015

Using electronic health records to investigate blood biomarkers and onset of cardiovascular diseases: example of differential white cell count

Shah, A. D.;
Open Access English
  • Published: 28 Nov 2015
  • Publisher: UCL (University College London)
  • Country: United Kingdom
Abstract
BACKGROUND: Electronic health records are invaluable for studying clinically recorded biomarkers and outcomes, but conversion of raw datasets to a research-ready format and replication of analyses can be challenging. The differential white cell count is a common blood test which may reflect inflammation and cardiovascular risk, but previous epidemiological studies have been small or in selected populations. AIM: To develop methods to assist in using electronic health record databases for research, and apply them to an exemplar study investigating differential white cell counts and onset of cardiovascular diseases. METHODS: The data source was CALIBER: linked ele...
Related Organizations
72 references, page 1 of 5

[65] Ammirati E, Moroni F, Magnoni M, Camici PG. The role of T and B cells in human atherosclerosis and atherothrombosis. Clin Exp Immunol. 2015;179(2):173-187. http://dx.doi.org/10.1111/cei.12477 . [OpenAIRE]

[66] Moretta L, Moretta A. Unravelling natural killer cell function: triggering and inhibitory human NK receptors. EMBO J. 2004 Jan;23(2):255-259. http://dx.doi. org/10.1038/sj.emboj.7600019 .

[67] Bobryshev YV, Lord RSA. Identification of natural killer cells in human atherosclerotic plaque. Atherosclerosis. 2005 Jun;180(2):423-427. http://dx.doi.org/10. 1016/j.atherosclerosis.2005.01.046 . [OpenAIRE]

[68] Seltzer MH, Bastidas JA, Cooper DM, Engler P, Slocum B, Fletcher HS. Instant nutritional assessment. J Parenter Enteral Nutr. 1979;3:157-159. http://pen. sagepub.com/content/3/3/157.long . [OpenAIRE]

[69] Vaduganathan M, Ambrosy AP, Greene SJ, Mentz RJ, Subacius HP, Maggioni AP, et al. The Predictive Value of Low Relative Lymphocyte Count in Patients Hospitalized for Heart Failure with Reduced Ejection Fraction: Insights from the EVEREST Trial. Circ Heart Fail. 2012;5:750-758.

[70] Núñez J, Núñez E, Bodí V, Sanchis J, Mainar L, Miñana G, et al. Low lymphocyte count in acute phase of ST-segment elevation myocardial infarction predicts longterm recurrent myocardial infarction. Coron Artery Dis. 2010 Jan;21(1):1-7.

[71] Tacke F, Alvarez D, Kaplan TJ, Jakubzick C, Spanbroek R, Llodra J, et al. Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques. J Clin Invest. 2007 Jan;117(1):185-194. http: //dx.doi.org/10.1172/JCI28549 .

[72] Rogacev KS, Cremers B, Zawada AM, Seiler S, Binder N, Ege P, et al. CD14++CD16+ monocytes independently predict cardiovascular events: A cohort study of 951 patients referred for elective coronary angiography. J Am Coll Cardiol. 2012;60(16):1512-1520.

[73] Swirski FK, Libby P, Aikawa E, Alcaide P, Luscinskas FW, Weissleder R, et al. Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata. J Clin Invest. 2007 Jan;117(1):195-205. http://dx.doi.org/10.1172/JCI29950 . [OpenAIRE]

[74] Nutman TB. Evaluation and differential diagnosis of marked, persistent eosinophilia. Immunol Allergy Clin North Am. 2007 Aug;27(3):529-549. http: //dx.doi.org/10.1016/j.iac.2007.07.008 . [OpenAIRE]

[75] Lee JJ, Jacobsen EA, McGarry MP, Schleimer RP, Lee NA. Eosinophils in health and disease: the LIAR hypothesis. Clin Exp Allergy. 2010 Apr;40(4).

[76] Kirkeby K, Paudal B. The eosinophil count in the diagnosis and prognosis of myocardial infarction. Acta Med Scand. 1960;168:21-24.

[77] Sakai T, Inoue S, Matsuyama TA, Takei M, Ota H, Katagiri T, et al. Eosinophils may be involved in thrombus growth in acute coronary syndrome. Int Heart J. 2009 May;50(3):267-277.

[78] Atkinson JB, Robinowitz M, McAllister HA, Virmani R. Association of eosinophils with cardiac rupture. Hum Pathol. 1985;16(6):562-8.

[79] Gudbjartsson DF, Bjornsdottir US, Halapi E, Helgadottir A, Sulem P, Jonsdottir GM, et al. Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. Nat Genet. 2009 mar;41(3):342-347. http://dx.doi.org/ 10.1038/ng.323 .

72 references, page 1 of 5
Abstract
BACKGROUND: Electronic health records are invaluable for studying clinically recorded biomarkers and outcomes, but conversion of raw datasets to a research-ready format and replication of analyses can be challenging. The differential white cell count is a common blood test which may reflect inflammation and cardiovascular risk, but previous epidemiological studies have been small or in selected populations. AIM: To develop methods to assist in using electronic health record databases for research, and apply them to an exemplar study investigating differential white cell counts and onset of cardiovascular diseases. METHODS: The data source was CALIBER: linked ele...
Related Organizations
72 references, page 1 of 5

[65] Ammirati E, Moroni F, Magnoni M, Camici PG. The role of T and B cells in human atherosclerosis and atherothrombosis. Clin Exp Immunol. 2015;179(2):173-187. http://dx.doi.org/10.1111/cei.12477 . [OpenAIRE]

[66] Moretta L, Moretta A. Unravelling natural killer cell function: triggering and inhibitory human NK receptors. EMBO J. 2004 Jan;23(2):255-259. http://dx.doi. org/10.1038/sj.emboj.7600019 .

[67] Bobryshev YV, Lord RSA. Identification of natural killer cells in human atherosclerotic plaque. Atherosclerosis. 2005 Jun;180(2):423-427. http://dx.doi.org/10. 1016/j.atherosclerosis.2005.01.046 . [OpenAIRE]

[68] Seltzer MH, Bastidas JA, Cooper DM, Engler P, Slocum B, Fletcher HS. Instant nutritional assessment. J Parenter Enteral Nutr. 1979;3:157-159. http://pen. sagepub.com/content/3/3/157.long . [OpenAIRE]

[69] Vaduganathan M, Ambrosy AP, Greene SJ, Mentz RJ, Subacius HP, Maggioni AP, et al. The Predictive Value of Low Relative Lymphocyte Count in Patients Hospitalized for Heart Failure with Reduced Ejection Fraction: Insights from the EVEREST Trial. Circ Heart Fail. 2012;5:750-758.

[70] Núñez J, Núñez E, Bodí V, Sanchis J, Mainar L, Miñana G, et al. Low lymphocyte count in acute phase of ST-segment elevation myocardial infarction predicts longterm recurrent myocardial infarction. Coron Artery Dis. 2010 Jan;21(1):1-7.

[71] Tacke F, Alvarez D, Kaplan TJ, Jakubzick C, Spanbroek R, Llodra J, et al. Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques. J Clin Invest. 2007 Jan;117(1):185-194. http: //dx.doi.org/10.1172/JCI28549 .

[72] Rogacev KS, Cremers B, Zawada AM, Seiler S, Binder N, Ege P, et al. CD14++CD16+ monocytes independently predict cardiovascular events: A cohort study of 951 patients referred for elective coronary angiography. J Am Coll Cardiol. 2012;60(16):1512-1520.

[73] Swirski FK, Libby P, Aikawa E, Alcaide P, Luscinskas FW, Weissleder R, et al. Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata. J Clin Invest. 2007 Jan;117(1):195-205. http://dx.doi.org/10.1172/JCI29950 . [OpenAIRE]

[74] Nutman TB. Evaluation and differential diagnosis of marked, persistent eosinophilia. Immunol Allergy Clin North Am. 2007 Aug;27(3):529-549. http: //dx.doi.org/10.1016/j.iac.2007.07.008 . [OpenAIRE]

[75] Lee JJ, Jacobsen EA, McGarry MP, Schleimer RP, Lee NA. Eosinophils in health and disease: the LIAR hypothesis. Clin Exp Allergy. 2010 Apr;40(4).

[76] Kirkeby K, Paudal B. The eosinophil count in the diagnosis and prognosis of myocardial infarction. Acta Med Scand. 1960;168:21-24.

[77] Sakai T, Inoue S, Matsuyama TA, Takei M, Ota H, Katagiri T, et al. Eosinophils may be involved in thrombus growth in acute coronary syndrome. Int Heart J. 2009 May;50(3):267-277.

[78] Atkinson JB, Robinowitz M, McAllister HA, Virmani R. Association of eosinophils with cardiac rupture. Hum Pathol. 1985;16(6):562-8.

[79] Gudbjartsson DF, Bjornsdottir US, Halapi E, Helgadottir A, Sulem P, Jonsdottir GM, et al. Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. Nat Genet. 2009 mar;41(3):342-347. http://dx.doi.org/ 10.1038/ng.323 .

72 references, page 1 of 5
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