publication . Other literature type . 2003

Human–Mouse Alignments with BLASTZ

Schwartz, Scott; Kent, W. James; Smit, Arian; Zhang, Zheng; Baertsch, Robert; Hardison, Ross C.; Haussler, David; Miller, Webb;
Open Access English
  • Published: 01 Jan 2003
  • Publisher: Cold Spring Harbor Laboratory Press
Abstract
The Mouse Genome Analysis Consortium aligned the human and mouse genome sequences for a variety of purposes, using alignment programs that suited the various needs. For investigating issues regarding genome evolution, a particularly sensitive method was needed to permit alignment of a large proportion of the neutrally evolving regions. We selected a program called BLASTZ, an independent implementation of the Gapped BLAST algorithm specifically designed for aligning two long genomic sequences. BLASTZ was subsequently modified, both to attain efficiency adequate for aligning entire mammalian genomes and to increase its sensitivity. This work describes BLASTZ, its ...
Subjects
free text keywords: Methods
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