publication . Other literature type . 2008

Genetic Variants Near TNFAIP3 on 6q23 are Associated with Systemic Lupus Erythematosus (SLE)

Graham, Robert R.; Cotsapas, Chris; Davies, Leela; Hackett, Rachel; Lessard, Christopher J.; Leon, Joanlise M.; Burtt, Noel P.; Guiducci, Candace; Parkin, Melissa; Gates, Casey; ...
Open Access English
  • Published: 01 Sep 2008
SLE is an autoimmune disease influenced by genetic and environmental components. We performed a genome-wide association scan (GWAS) and observed novel association evidence with a variant inTNFAIP3(rs5029939, P = 2.89×10−12, OR = 2.29). We also found evidence of two independent signals of association to SLE risk, including one described in Rheumatoid Arthritis. These results establish that genetic variation inTNFAIP3contributes to differential risk for SLE and RA.
Medical Subject Headings: skin and connective tissue diseases
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Other literature type . 2008
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