publication . Other literature type . 2005

Structure, function, and evolution of transient and obligate protein–protein interactions

Mintseris, Julian; Weng, Zhiping;
Open Access English
  • Published: 25 Jul 2005
  • Publisher: National Academy of Sciences
Recent analyses of high-throughput protein interaction data coupled with large-scale investigations of evolutionary properties of interaction networks have left some unanswered questions. To what extent do protein interactions act as constraints during evolution of the protein sequence? How does the type of interaction, specifically transient or obligate, play into these constraints? Are the mutations in the binding site of an interacting protein correlated with mutations in the binding site of its partner? We address these and other questions by relying on a carefully curated dataset of protein complex structures. Results point to the importance of distinguishi...
free text keywords: Biological Sciences
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