publication . Other literature type . 2014

Theoretical Impact of Florbetapir (18F) Amyloid Imaging on the Diagnosis of Alzheimer’s Dementia and the Detection of Preclinical Cortical Amyloid

Beach, Thomas G.; Schneider, Julie A.; Sue, Lucia I.; Serrano, Geidy; Dugger, Brittany N.; Monsell, Sarah E.; Kukull, Walter;
Open Access English
  • Published: 01 Oct 2014
Abstract
In 2012, florbetapir (18F) (Amyvid) received US FDA approval as a diagnostic agent for detecting neuritic (β-amyloid) plaques in live patients. Although such approval is specifically not extended to the usage of florbetapir as a single definitive diagnostic test for Alzheimer disease dementia (ADD), it is of considerable importance to examine its potential in this regard. To estimate the ability of florbetapir amyloid imaging to detect specified densities of postmortem-identified neuritic plaques, we used the data of Clark et al (2012). We then used the data of Beach et al (2012), derived from the National Alzheimer's Coordinating Center (NACC), to estimate the ...
Subjects
Medical Subject Headings: mental disorders
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Other literature type . 2014
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