publication . Other literature type . 2013

Update on hypothetical model of Alzheimer’s disease biomarkers

Jack, Clifford R.; Knopman, David S.; Jagust, William J.; Petersen, Ronald C.; Weiner, Michael W.; Aisen, Paul S.; Shaw, Leslie M.; Vemuri, Prashanthi; Wiste, Heather J.; Weigand, Stephen D.; ...
Open Access English
  • Published: 01 Feb 2013
Abstract
In 2010, the authors published a hypothetical model of the major biomarkers of Alzheimer’s disease (AD). The model was received with interest because we described the temporal evolution of AD biomarkers in relation to each other and to the onset and progression of clinical symptoms. In the interim, evidence has accumulated that supports the major assumptions of this model. Evidence has also appeared that challenges some of the assumptions underlying our original model. Recent evidence has allowed us to modify our original model. Refinements include indexing subjects by time rather than clinical symptom severity; incorporating inter-subject variability in cogniti...
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Other literature type . 2013
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