publication . Other literature type . 1998

Twenty proteins containing a C-terminal SOCS box form five structural classes

Hilton, Douglas J.; Richardson, Rachael T.; Alexander, Warren S.; Viney, Elizabeth M.; Willson, Tracy A.; Sprigg, Naomi S.; Starr, Robyn; Nicholson, Sandra E.; Metcalf, Donald; Nicola, Nicos A.;
Open Access English
  • Published: 06 Jan 1998
  • Publisher: National Academy of Sciences
Abstract
The four members of the recently identified suppressor of cytokines signaling family (SOCS-1, SOCS-2, SOCS-3, and CIS, where CIS is cytokine-inducible SH2-containing protein) appear, by various means, to negatively regulate cytokine signal transduction. Structurally, the SOCS proteins are composed of an N-terminal region of variable length and amino acid composition, a central SH2 domain, and a previously unrecognized C-terminal motif that we have called the SOCS box. By using the SOCS box amino acid sequence consensus, we have searched DNA databases and have identified a further 16 proteins that contain this motif. These proteins fall into five classes based on...
Subjects
Medical Subject Headings: otorhinolaryngologic diseasessense organsinorganic chemicalspsychological phenomena and processesbehavioral disciplines and activities
free text keywords: Biological Sciences
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Other literature type . 1998
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