publication . Other literature type . 2012

Alzheimer's Disease in Down Syndrome

Head, Elizabeth; Powell, David; Gold, Brian T.; Schmitt, Frederick A.;
Open Access English
  • Published: 01 Dec 2012
A key challenge to adults with Down syndrome (DS) as they age is an increased risk for cognitive decline, dementia, and Alzheimer disease (AD). In DS persons ranging from 40-49 years of age, 5.7-55% may be clinically demented and between 50-59 years, dementia prevalence ranges from 4-55% (reviewed in [1]). Despite the wide ranges reported for dementia prevalence, a consistent feature of aging in DS is the progressive accumulation of AD brain pathologies. By the age of 40 years, virtually all have sufficient senile plaques and neurofibrillary tangles for a neuropathological diagnosis of AD [2]. Thus, there is dissociation between the age of onset of AD neuropatho...
Medical Subject Headings: mental disorders
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Other literature type . 2012
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