publication . Other literature type . 1989

Mapping Mendelian Factors Underlying Quantitative Traits Using RFLP Linkage Maps

Lander, E. S.; Botstein, D.;
Open Access English
  • Published: 01 Jan 1989
The advent of complete genetic linkage maps consisting of codominant DNA markers [typically restriction fragment length polymorphisms (RFLPs)] has stimulated interest in the systematic genetic dissection of discrete Mendelian factors underlying quantitative traits in experimental organisms. We describe here a set of analytical methods that modify and extend the classical theory for mapping such quantitative trait loci (QTLs). These include: (i) a method of identifying promising crosses for QTL mapping by exploiting a classical formula of SEWALL WRIGHT; (ii) a method (interval mapping) for exploiting the full power of RFLP linkage maps by adapting the approach of...
free text keywords: Investigations
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Other literature type . 1989
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