publication . Article . 2002

Effect of polygenes on Xiong's transmission disequilibrium test of a QTL in nuclear families with multiple children.

Hong-Wen Deng; Jing Li; Robert R. Recker;
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  • Published: 11 Sep 2002 Journal: Genetic Epidemiology, volume 21, pages 243-265 (issn: 0741-0395, eissn: 1098-2272, Copyright policy)
  • Publisher: Wiley
Abstract
The transmission disequilibrium test (TDT), originally developed for mapping disease genes, has recently been extended to identify quantitative trait loci (QTL). For quantitative traits important for human health, generally multiple QTLs are involved. In the investigation of the statistical properties of the TDT, background polygenes (QTLs other than the QTL under test) generally have not been explicitly considered. The effects of background polygenes on the statistical properties of the TDT are thus largely unknown. Investigation of these effects will provide more realistic analyses of the statistical properties of the TDT under biologically plausible situation...
Subjects
Medical Subject Headings: stomatognathic diseases
free text keywords: Genetics(clinical), Epidemiology, Linkage disequilibrium, Polygene, Human health, Type I and type II errors, Nuclear family, Quantitative trait locus, Disease gene, Genetics, Biology, Transmission disequilibrium test
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