publication . Article . 2010

Interaction Between Ranitidine Hydrochloride and Bovine Serum Albumin in Aqueous Solution

Yaguang Sun;
  • Published: 11 May 2010 Journal: Journal of Solution Chemistry, volume 39, pages 654-664 (issn: 0095-9782, eissn: 1572-8927, Copyright policy)
  • Publisher: Springer Science and Business Media LLC
The interaction between ranitidine hydrochloride (RAN) and bovine serum albumin (BSA) in aqueous solution was investigated by means of fluorescence, synchronous fluorescence, and UV-Vis spectroscopy. The fluorescence of BSA was quenched remarkably by RAN and the quenching mechanism was concluded to be static quenching. The binding constants K and the number of binding sites n were calculated at three different temperatures. The RAN–BSA binding distance was determined to be less than 8 nm, suggesting that energy transfer may occur from BSA to RAN. The interaction process is spontaneous. Based on the obtained thermodynamic parameters, electrostatic forces may play...
free text keywords: Physical and Theoretical Chemistry, Biophysics, Biochemistry, Molecular Biology
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