publication . Article . 2017

Effects of cigarette smoke exposure during suckling on food intake, fat mass, hormones, and biochemical profile of young and adult female rats.

Manhaes AC; Patricia Lisboa; Egberto Moura;
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  • Published: 19 May 2017 Journal: Endocrine, volume 57, pages 60-71 (issn: 1355-008X, eissn: 1559-0100, Copyright policy)
  • Publisher: Springer Science and Business Media LLC
Abstract
Purpose Children from smoking mothers have a higher risk of developing obesity and associated comorbidities later in life. Different experimental models have been used to assess the mechanisms involved with this increased risk. Using a rat model of neonatal nicotine exposure via implantation of osmotic minipumps in lactating dams, we have previously shown marked sexual dimorphisms regarding metabolic and endocrine outcomes in the adult progeny. Considering that more than four thousand substances are found in tobacco smoke besides nicotine, we then studied a rat model of neonatal tobacco smoke exposure: adult male offspring had hyperphagia, obesity, hyperglycemia...
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