publication . Article . 1992

Evidence for nitric oxide synthase inhibitor-sensitive and insensitive hippocampal synaptic potentiation.

V. K. Gribkoff; J. T. Lum-Ragan;
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  • Published: 01 Aug 1992 Journal: Journal of Neurophysiology, volume 68, pages 639-642 (issn: 0022-3077, eissn: 1522-1598, Copyright policy)
  • Publisher: American Physiological Society
Abstract
<jats:p> 1. Nitric oxide (NO) has been proposed as a retrograde messenger, mediating the postsynaptic to presynaptic transfer of the effects of conditioning stimulation, responsible for the initiation of hippocampal long-term potentiation (LTP). To further test this hypothesis, we inhibited nitric oxide synthase (NOS) to determine whether synaptic potentiation produced by different conditioning stimulus patterns and intensities was differentially affected by reduction of stimulation-dependent NO production. 2. Synaptic potentiation was produced in hippocampal slices from young F-344 rats by two different conditioning stimulation protocols. Conditioning stimuli w...
Subjects
free text keywords: Physiology, General Neuroscience
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