publication . Article . 2011

Water, water, everywhere: sodium and water balance and the injured brain

Anne Claire Lukaszewicz; Didier Payen; Benjamin Soyer;
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  • Published: 08 Mar 2011 Journal: Current Opinion in Anaesthesiology, volume 24, pages 138-143 (issn: 0952-7907, Copyright policy)
  • Publisher: Ovid Technologies (Wolters Kluwer Health)
Abstract
PURPOSE OF REVIEW This review focuses on water shift and oedema in acute brain injury, with particular aspects on pathophysiology of water movements, the role of aquaporins and the potential of new therapies. This review reports on update of both significant experimental and clinical findings on factors implicated in oedema formation. RECENT FINDINGS The main inputs came from the demonstrated role of aquaporins (especially AQP4) in brain oedema control. The absence of aquaporin agonist or antagonist does not help to clarify the net effect of aquaporins on brain oedema. The clinical practice of osmotherapy, especially with hypertonic saline failed to improve neur...
Subjects
free text keywords: Anesthesiology and Pain Medicine, Intensive care medicine, medicine.medical_specialty, medicine, Randomized controlled trial, law.invention, law, Clinical Practice, business.industry, business, Osmotherapy, Inflammatory cascade, Hypertonic saline, Lesion, medicine.symptom, Brain oedema
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