publication . Article . 2006

inflammatory bowel disease and the apical junctional complex

M. BRUEWER; S. SAMARIN; A. NUSRAT;
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  • Published: 01 Aug 2006 Journal: Annals of the New York Academy of Sciences, volume 1,072, pages 242-252 (issn: 0077-8923, Copyright policy)
  • Publisher: Wiley
Abstract
: A critical function of the intestinal mucosa is to form a barrier that separates luminal contents from the underlying interstitium. This intestinal barrier is primarily regulated by the apical junctional complex (AJC) consisting of tight junctions (TJs) and adherens junctions (AJs) and is compromised in a number of intestinal diseases, including inflammatory bowel disease (IBD). In vitro studies have demonstrated that proinflammatory cytokines, such as interferon-gamma (IFN-γ) and tumor necrosis factor-alpha (TNF-α), that are increased in the intestinal mucosa of patients with IBD can induce a leaky mucosal barrier. There is a growing evidence that the increas...
Subjects
free text keywords: General Biochemistry, Genetics and Molecular Biology, History and Philosophy of Science, Proinflammatory cytokine, Pathology, medicine.medical_specialty, medicine, Tight junction, In vitro, Internalization, media_common.quotation_subject, media_common, Cell junction, Adherens junction, Immunology, Inflammatory bowel disease, medicine.disease, Tumor necrosis factor alpha, Biology
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