publication . Article . 2003

Effect of 5‐hydroxytryptamine on gastrointestinal motility in conscious guinea‐pigs

M. Nakajima; Y. Shiihara; Y. Shiba; I. Sano; T. Sakai; A. Mizumoto; Z. Itoh;
  • Published: 02 Nov 2003 Journal: Neurogastroenterology and Motility, volume 9, pages 205-214 (issn: 1350-1925, eissn: 1365-2982, Copyright policy)
  • Publisher: Wiley
Many studies have suggested that 5-hydroxytryptamine (5HT, serotonin) plays an important role in the control of gastrointestinal motility. However, most of these studies have been carried out on guinea-pig ileum in vitro. Therefore, we investigated the mechanisms of action of 5HT on gastrointestinal motility in conscious guinea-pigs. In order to investigate the effects of 5HT on gastrointestinal motility, extraluminal force transducers were sutured onto the serosal surfaces of the gastric antrum, duodenum and ileum and 5HT was infused intravenously. One of three types of 5HT antagonist or atropine was given before a 5HT infusion of 3.0 μg kg−1 min−1 was started....
Medical Subject Headings: digestive, oral, and skin physiologydigestive system
free text keywords: Gastroenterology, Physiology, Endocrine and Autonomic Systems, Serotonin, Endocrinology, medicine.medical_specialty, medicine, Ketanserin, medicine.drug, Duodenum, medicine.anatomical_structure, Antrum, Methysergide, Ileum, Internal medicine, business.industry, business, Pyloric Antrum, 5-HT receptor
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