publication . Article . 2008

Immunotherapy of equine sarcoid: dose-escalation trial for the use of chimeric papillomavirus-like particles

Stephanie Mattil-Fritz; Lutz Gissmann; Martin Müller; Konrad Piuko; Doreen Scharner; Hermann J. Müller; Nadja Thönes;
Open Access
  • Published: 01 Jan 2008 Journal: Journal of General Virology, volume 89, pages 138-147 (issn: 0022-1317, eissn: 1465-2099, Copyright policy)
  • Publisher: Microbiology Society
Abstract
<jats:p>Equine sarcoids are fibrosarcoma-like skin tumours with a prevalence of approximately 1–2 %. Strong evidence exists for a causative role of bovine papillomavirus (BPV) type 1 or type 2 in the development of sarcoids. No effective treatment of equine sarcoid is available and after surgical excision relapse of the tumours is very frequent. We developed chimeric virus-like particles (CVLPs) of BPV 1 L1–E7 for the immunotherapy of equine sarcoid. In a phase I clinical trial 12 horses suffering from equine sarcoid with an average number of more than 22 tumours per animal were vaccinated in a dose-escalation setting. The animals were followed-up for 63 days, e...
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free text keywords: Virology, Immunotherapy, medicine.medical_treatment, medicine, Phases of clinical research, Biology, Horse, Immunology, Dose escalation, Immune system, Antibody, biology.protein, Bovine papillomavirus, biology.organism_classification, Virus
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