publication . Article . 2003

Serotonin stimulates migrating myoelectric complex via 5-HT3-receptors dependent on cholinergic pathways in rat small intestine.

  • Published: 12 Mar 2003 Journal: Neurogastroenterology & Motility, volume 11, pages 1-10 (issn: 1350-1925, eissn: 1365-2982, Copyright policy)
  • Publisher: Wiley
We have investigated the effect of 5-hydroxytryptamine (5-HT) and different 5-HT-receptor antagonists and atropine on the migrating myoelectric complex in the rat small intestine. Infusion of 5-HT dose-dependently shortened the interval between phase III of the migrating myoelectric complex (MMC). In untreated animals the interval in upper jejunum was 19.1 (16.0–22.1) min. At doses of 10 and 20 nmol kg–1 min–1, the interval decreased to 15.2 (12.0–18.4) and 10.2 (9.4–11.0) min, respectively. The 5-HT3-receptor antagonist ondansetron (0.5 mg kg–1) alone increased the MMC interval from 20.8 (15.1–26.5) to 33.9 (19.4–48.4) min. Neither methiothepin (0.5 mg kg–1) no...
Medical Subject Headings: heterocyclic compounds
free text keywords: Gastroenterology, Physiology, Endocrine and Autonomic Systems, Internal medicine, medicine.medical_specialty, medicine, Antagonist, Biology, Endocrinology, Migrating motor complex, Jejunum, medicine.anatomical_structure, Serotonin, 5-HT receptor, Small intestine, Cholinergic, Ketanserin, medicine.drug
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