publication . Article . 2009

Cortical Thickness Analysis to Detect Progressive Mild Cognitive Impairment: A Reference to Alzheimer's Disease

Valtteri Julkunen; Miia Kivipelto;
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  • Published: 09 Nov 2009 Journal: Dementia and Geriatric Cognitive Disorders, volume 28, pages 404-412 (issn: 1420-8008, eissn: 1421-9824, Copyright policy)
  • Publisher: S. Karger AG
Abstract
Background/Aims: Mild cognitive impairment (MCI) is associated with an increased risk of Alzheimer’s disease (AD). It would be advantageous to be able to distinguish the characteristics of those MCI patients with a high probability to progress to AD if one wishes to monitor the disease development and treatment. Methods: We assessed the baseline MRI and maximum of 7 years clinical follow-up data of 60 MCI subjects in order to examine differences in cortical thickness (CTH) between the progressive MCI (P-MCI) and stable MCI (S-MCI) subjects. CTH was measured using an automatic computational surface-based method. During the follow-up, 15 MCI subjects converted to ...
Subjects
Medical Subject Headings: mental disordersbehavioral disciplines and activitieshuman activitiesnervous system diseases
free text keywords: Cognitive Neuroscience, Geriatrics and Gerontology, Psychiatry and Mental health
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