publication . Article . 2003

temporal cortex hypermetabolism in down syndrome prior to the onset of dementia

R. J. Haier; M. T. Alkire; N. S. White; M. R. Uncapher; E. Head; I. T. Lott; C. W. Cotman;
  • Published: 22 Dec 2003 Journal: Neurology, volume 61, pages 1,673-1,679 (issn: 0028-3878, eissn: 1526-632X, Copyright policy)
  • Publisher: Ovid Technologies (Wolters Kluwer Health)
Background: Adults with Down syndrome (DS) are at increased risk for dementia and provide an opportunity to identify patterns of brain activity that may precede dementia. Studies of early Alzheimer’s disease (AD) and risk of AD show decreased function in posterior cingulate and temporal cortex as initial indicators of the disease process, but whether the origin and sequence of predementia brain changes are the same in DS is unknown. Methods: The regional cerebral glucose metabolic rates (GMR) among middle-aged nondemented people with DS (n = 17), people with moderate AD (n = 10), and age-matched control subjects (n = 24) were compared using PET during a cognitiv...
free text keywords: Clinical Neurology, Hypermetabolism, Temporal cortex, Physical therapy, medicine.medical_specialty, medicine, Internal medicine, Neuroscience, Statistical parametric mapping, business.industry, business, Brain activity and meditation, Cardiology, Posterior cingulate, Dementia, medicine.disease, Entorhinal cortex, Down syndrome
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