publication . Article . 2006

Fibroblast growth factors, fibroblast growth factor receptors, diseases, and drugs.

Gregory Chen; Reza Forough;
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  • Published: 01 Jun 2006 Journal: Recent Patents on Cardiovascular Drug Discovery, volume 1, pages 211-224 (issn: 1574-8901, Copyright policy)
  • Publisher: Bentham Science Publishers Ltd.
Abstract
: Maintenance of endothelial cells (ECs), the building blocks of the vascular tree, is a presumed function of fibroblast growth factors (FGFs). In particular, the two prototypic members of FGF family, namely FGF1 and FGF2, due to their potent mitogenic and pro-migratory activities, have the ability to induce metabolic and phenotypic changes in ECs that are required to stimulate angiogenesis. In addition to FGF1 and FGF2, 23 other members of the FGF family have since been identified and characterized and they are reviewed in relation to their disease pathology. Particular emphasis is given to the biology of the FGFs and FGFRs on how they mediate the onset of angi...
Subjects
free text keywords: Pharmacology (medical), Drug Discovery, Cardiology and Cardiovascular Medicine
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