publication . Article . 2007

clustering migration and neurite formation of neural precursor cells in the adult rat hippocampus

Tatsunori Seki; Takashi Namba; Hideki Mochizuki; Masafumi Onodera;
  • Published: 08 Mar 2007 Journal: The Journal of Comparative Neurology, volume 502, pages 275-290 (issn: 0021-9967, eissn: 1096-9861, Copyright policy)
  • Publisher: Wiley
Adult neurogenesis occurs in the subgranular zone and innermost part of the dentate granule cell layer. To examine how neural precursor cells proliferate, migrate, and extend their neurites, we performed BrdU- and improved retrovirus-green fluorescence protein (GFP)-labeling analyses. Soon after labeling the majority of BrdU cells and GFP cells expressed Ki67, a cell cycle marker, and formed clusters together with PSA neuroblasts. Most of the Ki67 proliferating cells expressed Hu, an immature and mature neuronal marker, and the subpopulation expressed both Hu and GFAP. In the clusters, Ki67 and PSA cells strongly expressed -catenin and N-cadherin, but PSA cells ...
free text keywords: Stem cell, Subgranular zone, medicine.anatomical_structure, medicine, Biology, Neurite, Neuroscience, Neuroblast, Granule cell, Hippocampal formation, Anatomy, Cell aggregation, Neurogenesis
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