publication . Article . 2006

catabolism of adenine nucleotides favors adenosine production following exercise in patients with chronic heart failure

Toru Kinugawa; Masashi Fujita; Kazuhide Ogino; Masahiko Kato; Shuichi Osaki; Osamu Igawa; Chiaki Shigemasa; Ichiro Hisatome; Masafumi Kitakaze;
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  • Published: 15 Dec 2006 Journal: Journal of Cardiac Failure, volume 12, pages 720-725 (issn: 1071-9164, Copyright policy)
  • Publisher: Elsevier BV
Abstract
Abstract Background Adenosine 5′-triphosphate is catabolized to adenosine 5′-monophosphate (AMP), which is further degraded by 2 pathways: deamination to inosine 5′-monophosphate and ammonia by AMP deaminase, or dephosphorylation to adenosine and inorganic phosphate by 5′-nucleotidase. Because adenosine is believed to be cardioprotective and we have reported that ammonia production decreased after exercise in patients with chronic heart failure (CHF), we determined if plasma adenosine levels after exercise increases in patients with CHF. Methods and Results Maximal ergometer exercise tests with expired gas analysis were performed in 51 patients with CHF (age = 6...
Subjects
free text keywords: Cardiology and Cardiovascular Medicine, Dephosphorylation, Cardiology, medicine.medical_specialty, medicine, Adenosine, medicine.drug, Internal medicine, Diabetes mellitus, medicine.disease, Catabolism, business.industry, business, Heart failure, AMP deaminase, Endocrinology, Adenine nucleotide, Inosine
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