publication . Article . 2002

HYDROGELS FOR COLON-SPECIFIC ORAL DRUG DELIVERY: SYNTHESIS AND CHARACTERIZATION

Smt. J. Sonkusley; Sunil Kumar Bajpai;
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  • Published: 26 Jul 2002 Journal: Journal of Macromolecular Science, Part A, volume 38, pages 365-381 (issn: 1060-1325, eissn: 1520-5738, Copyright policy)
  • Publisher: Informa UK Limited
Abstract
Hydrogels have been synthesized by free radical co-polymerization of acrylamide and maleic acid in the presence of poly(N-vinyl-2-pyrrolidone) in aqueous medium. The presence of a small amount of maleic acid in the polymer network increased the swelling capacity appreciably, thus changing the Fickian swelling behavior to a non-Fickian one. The hydrogels showed good response to pH, ionic-strength and valency of counterions in the external media. The hydrogels demonstrated minimum swelling in the strongly acidic range 1–2 and maximum swelling was observed in the neutral or slightly alkaline medium (7–8). The amount of maleic acid in the hydrogel affected its swell...
Subjects
Medical Subject Headings: technology, industry, and agriculturemacromolecular substances
free text keywords: Ionic strength, Nuclear chemistry, Maleic acid, chemistry.chemical_compound, chemistry, Swelling capacity, Ionomer, Swelling, medicine.symptom, medicine, Drug carrier, Self-healing hydrogels, Acrylamide, Materials science, Polymer chemistry
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