publication . Article . 2002

A genome-wide screen reveals evidence for a locus on chromosome 11 influencing variation in LDL cholesterol in the NHLBI Family Heart Study.

Hilary Coon; Richard H. Myers;
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  • Published: 31 Jul 2002 Journal: Human Genetics, volume 111, pages 263-269 (issn: 0340-6717, eissn: 1432-1203, Copyright policy)
  • Publisher: Springer Science and Business Media LLC
Abstract
A genome scan was performed for low-density lipoprotein cholesterol concentration (LDL-C) in white subjects who were ascertained through the NHLBI Family Heart Study (FHS). The NIH Mammalian Genotyping Service (Marshfield, Wis.) genotyped 401 autosomal markers spaced at approximate 10-cM intervals. Additional FHS families were genotyped by the FHS Molecular Laboratory at the University of Utah for 243 markers; 645 subjects were typed in both laboratories so that a combined map of the 644 markers from the two screening sets (average distance of 5.46 cM) could be produced. Analyses were done on 2,799 genotyped subjects in 500 families where at least two genotyped ...
Subjects
free text keywords: Genetics(clinical), Genetics
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