publication . Article . 2011

respiratory motoneurons and pathological conditions lessons from hypoglossal motoneurons challenged by excitotoxic or oxidative stress

Alessandra Cifra; Francesca Nani; Andrea Nistri;
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  • Published: 02 Apr 2011 Journal: Respiratory Physiology & Neurobiology, volume 179, pages 89-96 (issn: 1569-9048, Copyright policy)
  • Publisher: Elsevier BV
Abstract
Hypoglossal motoneurons (HMs) are respiration-related brainstem neurons that command rhythmic contraction of the tongue muscles in concert with the respiratory drive. In experimental conditions, HMs can exhibit a range of rhythmic patterns that may subserve different motor outputs and functions. Neurodegenerative diseases like amyotrophic lateral sclerosis (ALS; Lou-Gehrig disease) often damage HMs with distressing symptoms like dysarthria, dysphagia and breathing difficulty related to degeneration of respiratory motoneurons. While the cause of ALS remains unclear, early diagnosis remains an important goal for potential treatment because fully blown clinical sym...
Subjects
free text keywords: Physiology, General Neuroscience, Pulmonary and Respiratory Medicine, Amyotrophic lateral sclerosis, medicine.disease, medicine, Neurotransmission, Glutamate receptor, Neuroscience, Metabotropic glutamate receptor, Excitotoxicity, medicine.disease_cause, Anesthesia, Brainstem, Neuroprotection, Riluzole, medicine.drug, business.industry, business
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