publication . Article . 2013

Origin and migration ofGfap+progenitors

Tatsunori Seki; Toru Sato; Keiko Toda; Noriko Osumi; Tetsuya Imura; Seiji Shioda;
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  • Published: 06 Dec 2013 Journal: Journal of Comparative Neurology, volume 522, pages 261-283 (issn: 0021-9967, Copyright policy)
  • Publisher: Wiley
Abstract
In the adult hippocampus, granule cells continue to be generated from astrocyte-like progenitors expressing glial fibrillary acidic protein (GFAP) that differ from embryonic neocortical progenitors. However, during the embryonic period, dentate granule neurons and neocortical pyramidal neurons are derived from the ventricular zone (VZ) of the pallium. Our question is when do GFAP+ progenitors of granule neurons appear in the developing hippocampus during the embryonic period, and how do they form the granule cell layer. The present analysis using Gfap-GFP transgenic mice shows that the GFP+ distinct cell population first appears in the VZ of the medial pallium a...
Subjects
Medical Subject Headings: nervous system
free text keywords: General Neuroscience, SOX2, Stem cell, Glial fibrillary acidic protein, biology.protein, biology, Anatomy, Neuroscience, NeuroD, Granule cell, medicine.anatomical_structure, medicine, Dentate gyrus, Hippocampus, Population, education.field_of_study, education
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