publication . Article . 2005

influence of acute serotonin reuptake inhibition on colonic sensorimotor function in man

J. TACK; D. BROEKAERT; M. CORSETTI; B. FISCHLER; J. JANSSENS;
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  • Published: 22 Dec 2005 Journal: Alimentary Pharmacology and Therapeutics, volume 23, pages 265-274 (issn: 0269-2813, eissn: 1365-2036, Copyright policy)
  • Publisher: Wiley
Abstract
Summary Background  It is unclear whether decreased serotonin transporter function contributes to sensorimotor abnormalities in irritable bowel syndrome. Aim  To study the influence of acute serotonin transporter inhibition on colonic sensorimotor function in man. Methods  Ten healthy subjects (five men, aged 20–29 years) underwent a combined manometry/barostat study of the descending colon on two occasions. Stepwise distentions by 2 mmHg increments were performed until discomfort. Subsequently, placebo or citalopram 20 mg were administered i.v. over 20 min and distentions were repeated. Afterwards, isobaric tone measurements were performed 30 min before and 90 ...
Subjects
free text keywords: Pharmacology (medical), Citalopram, medicine.drug, medicine, Serotonin transporter, biology.protein, biology, Serotonin, Endocrinology, medicine.medical_specialty, Internal medicine, Barostat, business.industry, business, Placebo, Neurotransmitter, chemistry.chemical_compound, chemistry, Contractility, Serotonin Uptake Inhibitors
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