publication . Article . 2007

genabel an r library for genome wide association analysis

Y. S. Aulchenko; S. Ripke; A. Isaacs; C. M. van Duijn;
Open Access
  • Published: 23 Mar 2007 Journal: Bioinformatics, volume 23, pages 1,294-1,296 (issn: 1367-4803, eissn: 1460-2059, Copyright policy)
  • Publisher: Oxford University Press (OUP)
Abstract
Here we describe an R library for genome-wide association (GWA) analysis. It implements effective storage and handling of GWA data, fast procedures for genetic data quality control, testing of association of single nucleotide polymorphisms with binary or quantitative traits, visualization of results and also provides easy interfaces to standard statistical and graphical procedures implemented in base R and special R libraries for genetic analysis. We evaluated GenABEL using one simulated and two real data sets. We conclude that GenABEL enables the analysis of GWA data on desktop computers. Availability: http://cran.r-project.org Contact: i.aoultchenko@erasmusmc....
Subjects
free text keywords: Single-nucleotide polymorphism, Bioinformatics, Genome-Wide Association Analysis, Data mining, computer.software_genre, computer, Quantitative trait locus, Computer science, Genetic data, Data set, Visualization, Genetic analysis
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