publication . Article . 2003

Species, strain and developmental variations in hippocampal neuronal and endothelial nitric oxide synthase clarify discrepancies in nitric oxide-dependent synaptic plasticity.

S Blackshaw; M.J.L Eliasson; A Sawa; C.C Watkins; D Krug; A Gupta; T Arai; R.J Ferrante; S.H Snyder;
  • Published: 03 Jun 2003 Journal: Neuroscience, volume 119, pages 979-990 (issn: 0306-4522, Copyright policy)
  • Publisher: Elsevier BV
Abstract Nitric oxide (NO) has been implicated in long-term potentiation (LTP) in pyramidal neurons in cellular area 1 (CA1) of the hippocampus. However, considerable confusion exists about the exact role of NO, and the contribution of the endothelial nitric oxide synthase (eNOS) and neuronal nitric oxide synthase (nNOS) isoforms of NO synthase to NO-dependent LTP (NO-LTP), with results often varying, depending on the organism and experimental paradigm used. Using immunohistochemistry and in situ hybridization, we contrast NO synthase expression and activity in rat, mouse, and human hippocampus. nNOS is prominently expressed in all CA1 pyramidal cells of C57B6 m...
Medical Subject Headings: nervous systemfood and beverages
free text keywords: General Neuroscience
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