publication . Article . 2013

Hepatitis B virus hepatotropism is mediated by specific receptor recognition in the liver and not restricted to susceptible hosts.

Alexa Schieck; Andreas Schulze; Caroline Gähler; Thomas Müller; Uwe Haberkorn; Alexander Alexandrov; Stephan Urban; Walter Mier;
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  • Published: 15 May 2013 Journal: Hepatology, volume 58, pages 43-53 (issn: 0270-9139, Copyright policy)
  • Publisher: Wiley
Abstract
The human hepatitis B virus (HBV) causes acute and chronic infections in humans and chimpanzees. HBV infects its hosts at minimal inoculation doses and replicates exclusively in hepatocytes. The viral determinants for the pronounced species specificity and the high efficacy to address hepatocytes in vivo are unknown. Previous findings showed that N-terminally myristoylated peptides constituting a receptor binding domain of the HBV large envelope (L)-protein block HBV entry in vitro and in vivo. Here we investigate the ability of such peptidic receptor ligands to target the liver. Injection of radioactively labeled HBVpreS-lipopeptides resulted in rapid accumulat...
Subjects
free text keywords: Hepatology
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