publication . Article . 2014

identification and characterization of the polyketide synthase involved in ochratoxin a biosynthesis in aspergillus carbonarius

Antonia Gallo; Benjamin P. Knox; Kenneth S. Bruno; Michele Solfrizzo; Scott E. Baker; Giancarlo Perrone;
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  • Published: 21 Mar 2014 Journal: International Journal of Food Microbiology, volume 179, pages 10-17 (issn: 0168-1605, Copyright policy)
  • Publisher: Elsevier BV
Abstract
Abstract Ochratoxin A (OTA) is a potent mycotoxin produced by Aspergillus and Penicillium species and is a common contaminant of a wide variety of food commodities, with Aspergillus carbonarius being the main producer of OTA contamination in grapes and wine. The molecular structure of OTA comprises a dihydroisocoumarin ring linked to phenylalanine and, as shown in different producing fungal species, a polyketide synthase (PKS) is a component of the OTA biosynthetic pathway. Similar to observations in other filamentous ascomycetes, the genome sequence of A. carbonarius contains a large number of genes predicted to encode PKSs. In this work a pks gene identified w...
Subjects
free text keywords: Food Science, Microbiology, General Medicine, Biology, Gene, Mycotoxin, chemistry.chemical_compound, chemistry, Polyketide synthase, biology.protein, Aspergillus niger, biology.organism_classification, Polyketide, Biochemistry, Aspergillus ochraceus, Aspergillus, Ochratoxin A
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