publication . Article . 2005

myocardial ischemia and reperfusion injury

L. Maximilian Buja;
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  • Published: 10 Jul 2005 Journal: Cardiovascular Pathology, volume 14, pages 170-175 (issn: 1054-8807, Copyright policy)
  • Publisher: Elsevier BV
Abstract
Abstract Myocardial ischemic injury results from severe impairment of coronary blood supply and produces a spectrum of clinical syndromes. As a result of intensive investigation over decades, a detailed understanding is now available of the complexity of the response of the myocardium to an ischemic insult. Myocardial ischemia results in a characteristic pattern of metabolic and ultrastructural changes that lead to irreversible injury. Recent studies have explored the relationship of myocardial ischemic injury to the major modes of cell death, namely, oncosis and apoptosis. The evidence indicates that apoptotic and oncotic mechanisms can proceed together in isch...
Subjects
free text keywords: Pathology and Forensic Medicine, Cardiology and Cardiovascular Medicine, General Medicine, Cardiology, medicine.medical_specialty, medicine, Coronary occlusion, Oncotic pressure, Necrosis, medicine.symptom, Reperfusion injury, medicine.disease, Ischemia, Programmed cell death, Myocyte, Endocardium, business.industry, business, Internal medicine
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