publication . Article . 2002

Different strains of rats show different sensitivity to block of long-term potentiation by nitric oxide synthase inhibitors

Christian Hölscher;
  • Published: 03 Dec 2002 Journal: European Journal of Pharmacology, volume 457, pages 99-106 (issn: 0014-2999, Copyright policy)
  • Publisher: Elsevier BV
Abstract Nitric oxide is presumed to play important roles in the induction of synaptic plasticity and learning. Previous publications, however, reported contradictory results. Block of nitric oxide synthase (NOS) has been shown to impair the induction of long-term potentiation of synaptic transmission in some studies. Other studies observed a partial block of long-term potentiation depending on experimental conditions, while yet other studies did not find an effect of NOS inhibitors under any conditions tested. Some reasons for these differences had been identified, e.g. the temperature of the slice buffer, the age of the animals, and the specific stimulation pr...
free text keywords: Pharmacology
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