publication . Article . 2018

Iron and Alzheimer's Disease: An Update on Emerging Mechanisms.

Ashley Bush; Scott Ayton; Darius Lane;
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  • Published: 12 Jun 2018 Journal: Journal of Alzheimer's Disease, volume 64, pages S379-S395 (issn: 1387-2877, eissn: 1875-8908, Copyright policy)
  • Publisher: IOS Press
Abstract
: Iron is a crucial transition metal for life and is the most abundant transition metal in the brain. However, iron's biological utility as an effective redox cycling metal also endows it with the potential to catalyze production of noxious free radicals. This "Janus-faced" nature of iron demands a tight regulation of cellular its metabolism. This regulation is crucial in the CNS, where iron plays myriad keystone roles in CNS processes, including mitochondrial energy transduction, enzyme catalysis, mitochondrial function, myelination, neurotransmitter anabolism and catabolism. Aberrations in brain iron homeostasis can elevate levels of this redox-active metal, l...
Subjects
free text keywords: Clinical Psychology, Geriatrics and Gerontology, Psychiatry and Mental health, General Medicine
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