publication . Article . 2005

Prospects for vaccine development against Buruli disease

Kris Huygen;
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  • Published: 13 Jan 2005 Journal: Expert Review of Vaccines, volume 2, pages 561-569 (issn: 1476-0584, eissn: 1744-8395, Copyright policy)
  • Publisher: Informa UK Limited
Abstract
Buruli disease, caused by Mycobacterium ulcerans, is an emerging infectious disease in tropical areas, particularly West Africa, which can cause deep necrotizing skin lesions, called Buruli ulcer. Buruli disease affects all age groups but about 50% of the cases are diagnosed in children. There is no evidence that Buruli disease is transmitted by direct person-to-person contact and it is very likely that contaminated water of rivers, swamps and lakes serves as the wildlife reservoir of M. ulcerans. This review briefly discusses the epidemiology, microbiology, pathology and treatment of the disease. It describes in detail the current knowledge of the immune respon...
Subjects
Medical Subject Headings: skin and connective tissue diseasesbacterial infections and mycoses
free text keywords: Immunology, Molecular Medicine, Pharmacology, Drug Discovery
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